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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of diabetic retinopathy (DR)
ncRNA name Notch 1 siRNA
ncRNA Category siRNA
Disease name diabetic retinopathy (DR)
Species Homo sapiens
Tissues/Cell_line human retinal endothelial cells (HRECs)
Methods siRNA transfection, TUNEL assay, Western blot, qPCR
Expression pattern associated
Functional description The apoptosis of HRECs was significantly decreased in cells transfected with Notch 1 siRNA compared to the blank vector group, and the expression of inflammatory cytokines in cells was also significantly decreased.
PubMed ID 29932924
Year 2018
Title The role of uric acid in the pathogenesis of diabetic retinopathy based on Notch pathway.
Drug-related ncRNA NO

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